Regulation of inhibitory synapses by presynaptic D 4 dopamine receptors in 2 thalamus 3
نویسندگان
چکیده
a Beckman Institute for Advanced Science and Technology, b Department of Pharmacology 6 c Department of Molecular & Integrative Physiology, d Cell and Developmental Biology, 7 e Neuroscience Program 8 University of Illinois, Urbana, IL 61801 9 10 Running Head: Modulation of pallido-thalamic GABAergic transmission 11 12
منابع مشابه
Regulation of inhibitory synapses by presynaptic D₄ dopamine receptors in thalamus.
Dopamine (DA) receptors are the principal targets of drugs used in the treatment of schizophrenia. Among the five DA receptor subtypes, the D(4) subtype is of particular interest because of the relatively high affinity of the atypical neuropleptic clozapine for D(4) compared with D(2) receptors. GABA-containing neurons in the thalamic reticular nucleus (TRN) and globus pallidus (GP) express D(4...
متن کاملRegulation of Inhibitory Synapses by Presynaptic D4 Dopamine Receptors in Thalamus
Govindaiah G, Wang T, Gillette MU, Crandall SR, Cox CL. Regulation of inhibitory synapses by presynaptic D4 dopamine receptors in thalamus. J Neurophysiol 104: 2757–2765, 2010. First published September 8, 2010; doi:10.1152/jn.00361.2010. Dopamine (DA) receptors are the principal targets of drugs used in the treatment of schizophrenia. Among the five DA receptor subtypes, the D4 subtype is of p...
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The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...
متن کاملDopaminergic Presynaptic Modulation of Nigral Afferents: Its Role in the Generation of Recurrent Bursting in Substantia Nigra Pars Reticulata Neurons
PREVIOUS WORK HAS SHOWN THE FUNCTIONS ASSOCIATED WITH ACTIVATION OF DOPAMINE PRESYNAPTIC RECEPTORS IN SOME SUBSTANTIA NIGRA PARS RETICULATA (SNR) AFFERENTS: (i) striatonigral terminals (direct pathway) posses presynaptic dopamine D(1)-class receptors whose action is to enhance inhibitory postsynaptic currents (IPSCs) and GABA transmission. (ii) Subthalamonigral terminals posses D(1)- and D(2)-c...
متن کاملDopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses.
Circuit properties, such as the selection of motor synergies, have been posited as relevant tasks for the recurrent inhibitory synapses between spiny projection neurons of the neostriatum, a nucleus of the basal ganglia participating in procedural learning and voluntary motor control. Here we show how the dopaminergic system regulates short-term plasticity (STP) in these synapses. STP is though...
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تاریخ انتشار 2010